This activity is jointly provided by Global Education Group and PlatformQ Health Education, LLC, in collaboration with the National Organization for Rare Disorders, Inc (NORD).

ACKNOWLEDGEMENT

This activity is supported by an educational grant from Zogenix, Inc. – now a part of UCB

DATE OF RELEASE/EXPIRATION

This activity was released on May 16, 2022 and is valid until November 16, 2022. Requests for credit must be made no later than November 16, 2022.

TARGET AUDIENCE

The educational design of this activity addresses the needs of neurologists, pediatric neurologists, pediatricians and other health care professionals (including physicians, physicians-in-training, nurses, physician assistants, nurse practitioners, pharmacists, etc.) involved and/or interested in the management of patients with severe forms of pediatric intractable epilepsy.

STATEMENT OF NEED/PROGRAM OVERVIEW

Lennox‐Gastaut syndrome (LGS) is a difficult‐to‐manage form of childhood onset epilepsy. LGS is particularly challenging to diagnose and treat due to its multiple seizure types, associated comorbidities, and high morbidity and mortality burden. While an early diagnosis is key to the optimal management of childhood onset epilepsy, LGS is often diagnosed late and frequently confused with other seizure types.

In this continuing medical education activity, the expert faculty will discuss the importance of an early diagnosis of LGS, when treatments are most likely to alter the clinical course of the disease and prevent poor outcomes. Expert panelists will review the current treatment armamentarium for LGS to ensure clinicians are able to select the most appropriate first‐ and second-line options for patients with LGS. In addition, faculty will explore emerging data on investigational treatments with the potential to change practice and improve outcomes for patients with Dravet syndrome and LGS.

EDUCATIONAL OBJECTIVES

After completing this activity, the participant should be better able to:

• Explain the prevalence, clinical features, and importance of early diagnosis in LGS
• Select appropriate treatments with proven efficacy and safety in LGS
• Discuss emerging treatment options for LGS

PHYSICIAN ACCREDITATION STATEMENT

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Global Education Group (Global) and PlatformQ Health Education, LLC. Global is accredited by the ACCME to provide continuing medical education for physicians.

PHYSICIAN CREDIT DESIGNATION

Global Education Group designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

NURSING CONTINUING EDUCATION

Global Education Group is accredited with distinction as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation.

This educational activity for 1.0 contact hour is provided by Global Education Group. Nurses should claim only the credit commensurate with the extent of their participation in the activity.

PHARMACIST ACCREDITATION STATEMENT

Global Education Group is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

CREDIT DESIGNATION

Global Education Group designates this continuing education activity for 1.0 contact hour(s) (0.10 CEUs) of the Accreditation Council for Pharmacy Education. (Universal Activity Number - 0530-9999-22-003-H01-P)
This is a knowledge-based activity.

ESTIMATED TIME TO COMPLETE

This activity should take approximately 1 hour to complete.

INSTRUCTIONS TO RECEIVE CREDIT

In order to receive credit for this activity, the participant must (1) read the target audience, learning objectives, and disclosure statements, (2) complete the educational activity online, and (3) complete the post-test and activity evaluation. To receive AMA PRA Category 1 Credits™, participants must receive a score of 70% on the post-test. For pharmacist/ACPE learners, please check the CPE monitor for your CE credit within 60 days of the activity.

HARDWARE/SOFTWARE REQUIREMENTS

Participants will need a computer with a recent version of Adobe Flash installed, as well as an internet connection sufficient for streaming media.

FEE INFORMATION & REFUND/CANCELLATION POLICY

There is no fee for this educational activity.

DISCLOSURE OF CONFLICTS OF INTEREST

Global Education Group (Global) adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited CE, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous. All persons in a position to control the content of an accredited continuing education program provided by Global are required to disclose all financial relationships with any ineligible company within the past 24 months to Global. All financial relationships reported are identified as relevant and mitigated by Global in accordance with the Standards for Integrity and Independence in Accredited CE in advance of delivery of the activity to learners. The content of this activity was vetted by Global to assure objectivity and that the activity is free of commercial bias.

All relevant financial relationships have been mitigated.

The faculty have the following relevant financial relationships with ineligible companies:

Name of Faculty or Presenter	Reported Financial Relationship
Kelly G. Knupp, MD, MSCS, FAES Interim Co-Chief, Section of Child Neurology Co-Director, Neurology Research Associate Professor of Pediatrics and Neurology University of Colorado, Anschutz Medical Campus	Consulting Fee: Epygenix, Zogenix, Stoke, Encoded Contracted Research: Eisai, Zogenix, Stoke, Encoded
Joseph E. Sullivan, MD Professor of Neurology & Pediatrics University of California, San Francisco (UCSF) Director, UCSF Pediatric Epilepsy Center of Excellence Co-Director, PISCES Longitudinal Integrated Clerkship	Consulting Fee: Epilepsy Study Consortium, Encoded Therapeutics, Greenwich Biosciences, Epygenix Therapeutics, Invitae, Knopp Biosciences, Longboard, Asceneuron, Praxis, Supernus Contracted Research: Zogenix, Stoke Therapeutics, Marinus Pharmaceuticals, Bio-pharm Solutions, Encoded Therapeutics, Xenon, Takeda Stock Option Holder: Epygenix Therapeutics

The planners and managers have the following relevant financial relationships with ineligible companies:

Name of Planner or Manager	Reported Financial Relationship
Rhys Williams, RN, MSN, FNP	Nothing to disclose
Lindsay Borvansky	Nothing to disclose
Andrea Funk	Nothing to disclose
Liddy Knight	Nothing to disclose
Ashley Cann	Nothing to disclose
Eve Wilson	Nothing to disclose
Alissa Yost	Nothing to disclose

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group (Global) and PlatformQ Health Education, LLC do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

DISCLAIMER:

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

CONTACT INFORMATION

Accreditation Support:

For information about the accreditation of this program, please contact Global at 303-395-1782 or cme@globaleducationgroup.com

Technical Support:

For any technical issues or issues with your CME Certificate, please contact NeuroSeriesLive.com at 877-394-1306 or at Support@NeuroSeriesLive.com.